A distinction can be made between 'narrow' general acceptance that human evolution occurred, historically and 'broad' evolutionary ideas that stretch much further into all aspects of humanity, past and present human evolution. The broad perspective is beginning to make its pres The last twenty years have seen a resurgence of interest in human evolution in many aspects.
The shaping of human diversity: filters, boundaries and transitions
The broad perspective is beginning to make its presence felt, for example, through the developments in evolutionary genetics, evolutionary psychology and behavioural ecology. There must, therefore, be, among the variety of human adaptations, natures and behaviours, phenomena which are not susceptible to an evolutionary analysis, which are beyond the bounds of evolution.
The problem is, though, that we do not really know where that boundary lies. Here, the limits of human evolution are explored, using two approaches - first, finding where humans 'fit' the expectations of evolutionary principles; and second, applying evolutionary methods to particular human contexts, whilst looking for an evolutionary signal. Get A Copy. Paperback , 42 pages. More Details Other Editions 1.
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Sort order. The successful completion of the HapMap has its roots not only in the completion of the human genome sequence in , but also in the massive effort to characterize and catalog the millions of SNPs across the genome. Based on these initial data, the haplotype structure of the human genome was recognized as early as , leading directly to the formation of the International HapMap Consortium.
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Finally, methods for identifying the influence of natural selection on the human genome were described in Altshuler, Lander, Gabriel, Daly and many other Broad Institute scientists led or contributed significantly to all of these efforts, in addition to their role in the completion of the HapMap and demonstrations of its utility, as outlined above.
The consortium is also nearing completion of the Phase II HapMap that will contain nearly three times more SNPs than the initial version and will enable researchers to focus their gene searches even more precisely on specific regions of the genome. In line with the Broad Institute's commitment to building critical resources for the scientific community, HapMap data are freely available in several public databases, including the HapMap Data Coordination Center www.
Further information can also be found at the Broad Institute's web site www.
The U. For more details on the project's scientific design and rationale, see www. For a complete list of participating research organizations and funders, see www. PLoS Biology.
here Efficiency and power in genetic association studies. Calibrating a coalescent simulation of human genome sequence variation. Genome Research. The International HapMap Consortium. A haplotype map of the human genome. It pursues this mission by empowering creative young scientists to construct new and robust tools for genomic medicine, to make them accessible to the global scientific community, and to apply them to the understanding and treatment of disease.
The Institute is a research collaboration involving faculty, professional staff and students from throughout the MIT and Harvard academic and medical communities. The two universities govern it jointly. Organized around Scientific Programs and Scientific Platforms, the unique structure of the Broad Institute enables scientists to collaborate on transformative projects across many scientific and medical disciplines.
Skip to main content. Haplotype map brings new insights into human disease, evolution. By Broad Institute Communications. New software moves microarray analysis from individual genes to whole networks of genetic interactions.
David Altshuler comments on the HapMap. The International Common Disease Alliance launches, aims to accelerate understanding and treatment of common diseases. Read more.